About

Thera4Care specialises in advanced theranostic solutions, combining expert research with novel technologies to revolutionise healthcare. Our approach enhances precision in both diagnostics and treatments for complex diseases like cancer, utilising innovative isotopes and imaging techniques to improve patient outcomes.

Background

In an era where healthcare challenges are increasingly complex and the demand for personalised treatment is growing, Thera4Care stands out as a crucial initiative. Our project, launched in October 2024, is set to run for five years. We are at the very beginning of our journey, focusing on harnessing the collective expertise of leading academics, medical professionals, and technologists.

We are dedicated to innovating at the intersection of technology and patient care, developing solutions that are not only effective but also accessible and sustainable.

Thera4Care's work is particularly vital now, as it contributes to shaping a future where healthcare systems are more adaptive, treatments are more precise, and patient outcomes are significantly improved. As this project is in its initial phase, the expectation for immediate results, especially in terms of therapeutic solutions, must be tempered with an understanding that real impact takes time to manifest.

Our Methodology Overview

The Thera4Care project employs a thorough methodology to advance the application and integration of radiotheranostics into clinical practice for targeted cancer treatment. The methodology encompasses four primary pillars:

1. Regulation and Preclinical Research

This pillar focuses on ensuring compliance with regulatory requirements and facilitating the integration of radiotheranostics into clinical settings. It includes evaluating emerging radiotheranostic pairs such as 44Sc/161Tb, 61Cu/64Cu/67Cu, and 18F/211At in cancers with unmet clinical needs, like ovarian cancer, sarcoma, glioblastoma, as well as neuroendocrine and pancreatic cancer. Thera4Care aims to optimise these therapies to maximise therapeutic efficacy whilst minimising side effects.

2. Experimental Trials and Production

This pillar strengthens the production and supply chains within Europe, exploring cyclotron and generator-based production strategies. It emphasises the development of new radiotheranostic compounds with favourable beta emission ranges and focuses on conducting clinical trials to swiftly transition these innovations from preclinical stages to Phase I clinical trials.

3. Data Analysis and Technology

The project aims to create a Multi-Site FAIR Data-Sharing Database to integrate AI with existing imaging modalities, improve treatment and imaging techniques, and develop personalised dosimetry models. This integration facilitates advanced nuclear medicine imaging and data analysis, enhancing precision in cancer treatment.

4. Education and Training

Thera4Care intends to develop an educational platform, offering specialised courses and creating a network of theranostics centres. This platform will serve as a hub for disseminating scientific findings and training healthcare professionals, thereby promoting the standardisation and application of theranostics.

Our Work Packages

Thera4Care's project framework is structured around nine interconnected Work Packages (WPs), each dedicated to different facets of healthcare innovation—from regulatory compliance and preclinical research to clinical trials and technological advancements.

These WPs collaborate to streamline the transition of scientific discoveries from the lab to clinical settings, ensuring that all aspects of research, development, and implementation are aligned with stringent regulatory standards and real-world application needs.

By integrating cutting-edge technology, precise imaging, and robust educational strategies, we aim to create a holistic approach that enhances patient outcomes and leads to sustainable healthcare solutions.

WP1 Project Management

WP2 Regulatory

WP3 Preclinical investigation

WP4 Supply and production

WP5 Clinical trials

WP6 AI for treatment monitoring

WP7 Dosimetry

WP8 Precision imaging

WP9 Education, training, guidelines, and dissemination

Thera4Care Goes Beyond the State of the Art

Thera4Care significantly advances the current state of the art in radiotheranostics with innovative strategies that address existing limitations:

1. European Ecosystem for Radiotheranostics Advancement

Interdisciplinary Collaboration: Thera4Care promotes a unified platform that merges academic, healthcare, and industry sectors to enhance methodological consistency and research outcomes.
Accelerated Access to Radiotheranostics: By reducing development and deployment timelines from five to two years, Thera4Care aims to fast-track clinical trials and treatments, reinforcing Europe's leadership in this sector.

2. Enhanced Manufacturing and Clinical Deployment

Supply Chain Optimisation: Addresses logistical and technical challenges in radioisotope production to minimise waste and enhance cost-effectiveness.
Global Leadership in Radiotheranostics: Strengthens European capacities through rigorous investigations and robust manufacturing protocols.

3. Preclinical and Clinical Integration

Innovative Cancer Models: Incorporates advanced patient-derived and animal-free systems to improve strategic alignment of radiotherapy.
Radiobiological Assessment: Thera4Care conducts comparative studies to optimise radiotheranostic treatments, establishing benchmarks for efficacy and safety.

4. Phase I Clinical Trials and Beyond

Adaptive Trial Designs: Introduces more efficient frameworks that accelerate efficacy and safety assessments.
Multi-Centre Collaboration: Ensures diverse patient demographics in trials, enhancing robustness and generalisability of our findings.

5. Optimisation of Radiotheranostics Clinical Use

AI-Driven Decision Support Systems: Utilises AI to refine treatment strategies and enhance precision in medicine.
Comparative Dosimetric Studies: Conducts in-depth studies to tailor treatments and optimise patient outcomes.

Expected Outcomes When the Project Ends

enhanced treatment outcomes

Thera4Care aims to improve treatment efficacy and reduce time-to-treat through the development and clinical trials of innovative radiotheranostic solutions for various cancers.

advanced professional training

The project will develop and deliver extensive training and education to healthcare professionals on applying new radiotheranostic treatments effectively.

improved system affordability

Thera4Care focuses on enhancing the availability and cost-effectiveness of radiotheranostic solutions across Europe by advancing production techniques and supply chain integration.

optimised disease management

Advances in technology and data integration will enhance disease sensitivity and management, benefiting practitioners and patients with better stratification and staging.